ea0056p108 | Clinical case reports - Thyroid/Others | ECE2018
Serrano Ana Ruiz
, Ciccia Alessandra Gabillo
, Maduena Francisca Martinez
, Gonzalez Salome Martinez
, Ambros Josep Oriola
, Simon-Muela Inmaculada
, Ortega Joan Vendrell
, Cortes Silvia Naf
, Alevras Theodora Michalopoulou
, Colet Ana Megia
Introduction: The Carney-Stratakis syndrome (CSS) is an inherited condition caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C or D that predispose to gastric stromal tumors (GIST) and multicentric paragangliomas (PGL). SDH acts as a tumor suppressor gene, and enzyme activity reduction is known to be oncogenic. Since 2002 there has been some scarce reports. We present a new case of CSS associated with a germline unknown significance mutation in exon 4 ...